Krum et al. 1992; Australia
PEDro = 9
RCT
N=15

Population: Level of injury: T6 or above, at least 2 episodes of AD in last 7 days.
Treatment: double-blind, randomized to Prazosin 3 mg bid. (n=8) or placebo (n=7) for 2 weeks.
Outcome Measures: frequency and severity of AD, blood pressure

1. Prazosin was well tolerated and did not significantly lower resting BP. Compared to baseline, the Prazosin group had fewer severe episodes of AD (reduced rise in BP, shorter symptom duration and less need for acute antihypertensive medication).
2. The severity of headache during individual AD episodes was also diminished with Prazosin therapy.