Heterotopic Ossification Table 2 Warfarin as a Prophylaxis

Submitted by admin on Thu, 05/20/2010 - 00:25

Author Year
Country
Score
Research Design
Total Sample Size

Methods

Outcome

Buschbacher et al. 1992 USA
Downs & Black score=9
Observational
N=227

Population: Age = 17-75 yrs; Gender males = 94%, females = 6%; Severity of injury: complete, incomplete.
Treatment: Patients treated with warfarin for 5.4 weeks (mean time) post-SCI for DVT with no X-rays taken to rule out HO. HO diagnostic tests only if clinical signs suggested.
Outcome Measures: Prevalence of HO.
  1. Warfarin administration and development of HO were found to be significantly related (p<.01). 
  2. None of the pts treated with Warfarin (n=33) developed HO and none of the patients with HO (n=34) had been treated with Warfarin.

Note: DVT=deep venous thromoembolism