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Sautter-Bihl et al. 2001
Germany
Downs & Black score =12
Case series
N=52
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Population: Mean age = 33 yrs; Gender: males = 44, females = 8;
Treatment: Patients received single dose of radiotherapy between 2 to 10 Gy through a linear accelerator at 6-8 MV photons.
Outcome Measures: Efficacy, Brooker score, adverse effects.
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Prevention of HO was seen in 71% (41 primarily treated and 9 resected) joints.
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Radiotherapy treatment did not result in a regression of the Brooker score in any patient.
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An increase in two Brooker score grades was seen in two joints (1 knee, 1 hip).
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No adverse effects due to therapy occurred.
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16 of 32 hips treated only with radiotherapy (50%) did not show any abnormalities on follow-up.
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No progression of HO was noted in 30/36 subjects (83%).
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Reossification after therapy, which led to a decrease in joint mobility was noted in 3 subjects.
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Sautter-Bihl et al. 2000
Germany
Downs & Black score =9
Case series
N=36
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Population: Age = 17-59 yrs; Gender: males = 32, females = 4; Follow-up = 4-98 months.
Treatment: 25/36 subjects received 10 Gy in fraction of 2-2.5Gy, while 4 pts received higher doses. In phase 2- 7 subjects received a single does of irradiation with 8Gy. In total 46 joints were irradiated.
Outcome Measures: Progression of HO, complications.
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No statistically significant results reported.
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16 of the 32 hips treated with radiotherapy only did not show any abnormalities on F/U
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No progression of HO was noted in 30/36 subjects.
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Reossification after therapy, which led to a decrease in joint mobility, was noted in 3 subjects.
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