Methods of Systematic Review Table 1 Five levels of evidence
Level |
Research Design |
Description |
Level 1 |
Randomized controlled trial (RCT) |
Randomized controlled trial, PEDro score ³ 6. Includes within subjects comparison with randomized conditions and cross-over designs |
Level 2 |
RCT |
Randomized controlled trial, PEDro score < 6. |
Prospective controlled trial |
Prospective controlled trial (not randomized) |
|
Cohort |
Prospective longitudinal study using at least 2 similar groups with one exposed to a particular condition. |
|
Level 3 |
Case control |
A retrospective study comparing conditions, including historical controls |
Level 4 |
Pre-post |
A prospective trial with a baseline measure, intervention, and a post-test using a single group of subjects. |
Post-test |
A prospective post-test with two or more groups (intervention followed by post-test and no re-test or baseline measurement) using a single group of subjects. |
|
Case Series |
A retrospective study usually collecting variables from a chart review. |
|
Level 5 |
Observational |
Study using cross-sectional analysis to interpret relations. |
Clinical Consensus |
Expert opinion without explicit critical appraisal, or based on physiology, biomechanics or "first principles" |
|
Case Report |
Pre-post or case series involving one subject |